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The dna in a cell’s nucleus encodes proteins that are eventually targeted to every membrane and compartment in the cell, as well as proteins that are targeted for secretion from the cell. for example, consider these two proteins: phosphofructokinase (pfk) is an enzyme that functions in the cytoplasm during glycolysis. insulin, a protein that regulates blood sugar levels, is secreted from specialized pancreatic cells. assume that you can track the cellular locations of these two proteins from the time that translation is complete until the proteins reach their final destinations.for each protein, identify its targeting pathway: the sequence of cellular locations in which the protein is found from when translation is complete until it reaches its final (functional) destination. (note that if an organelle is listed in a pathway, the location implied is inside the organelle, not in the membrane that surrounds the organelle.)

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Approximately 90% of all cases of polycystic kidney disease are inherited in an autosomal dominant fashion. the disease is typically related to mutations to genes (pkd1 and pkd2). pkd genes can be found on chromosome 16. the disease occurs in approximately 1: 800 to 1: 1000 people. here is a hypothetical example. the dominant allele d will cause the development of pkd. the recessive allele is known as d. what genotypes would correspond to suffering from pkd? dd, dd what genotypes would correspond to being normal (not suffering from pkd)? dd consider that 1: 1,000 people have pkd in your population of 325million. consider that pkd is inherited in an autosomal dominant fashion. show you math for all of the following questions: what is the genotypic frequency for dd? what is the genotypic frequency for dd? what is the genotypic frequency for dd? what is p? what is q? how many people in your population would have pkd?