A. One of the late symptoms of MN is excessive edema, or build up of fluid within the interstitial space of tissue. Explain how loss of circulating blood protein (hypoalbuminemia) would cause edema with respect to hydrostatic and colloid osmotic pressure within capillary beds throughout the body.

Albumin is a protein that attracts water in the compartment where it is found, that is why when circulating within the blood vessels the blood volume is maintained by this protein, so that the liquid or fluid that makes up the blood volume is retained within the capillaries due to hydrostatic forces and because the albumin protein is hydrophilic.

The albumin is decreasing, that is, in deficit or hypoalbulinemia, less water reaches the blood compartment, therefore the blood pressure or pressure will drop, the blood volume will decrease but not due to loss of it as in hemorrhages, but due to diffusion to other compartments. VASCULAR through the processes of OSMOSIS, in simple words, when this protein descends, water filters from the blood vessels to extravascular compartments, this phenomenon clinically manifests itself as EDEMA.

Explanation:

Hypoalbulinemia also occurs in severe nutritional disorders where ovalbumine is not consumed through the egg, since the person's diet is severely lacking, generating massive edema in the abdominal area or abdominal distension.

The effect that the plasma liquid has in spreading to extravascular spaces is called OSMOSIS, which draws water from the external environment by the oncotic pressure generated by other proteins.

The oncotic pressure is the pressure that is generated when the water diffuses from one compartment to another by attraction of a protein, it happens both with albumin and with other proteins of the organism that are characterized by being hydrophilic or attracting water.

Hypoalbulinemia destroys severe cardiac symptoms due to the high demand that an increase in edema and difficulty of venous return entail along with the fall in blood pressure.

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