Your research group is investigating the possible use of genetically - engineered cells to produce a vaccine for malaria. In paragraph form, explain the pros AND cons of using E. coli, Saccharomyces, AND animal cells to produce the vaccine.

Attributes of E. coli articulation frameworks  

Advantages:

Quick articulation   Simplicity of culture   Significant returns   Cheap   Genome alterations conceivable   Large scale manufacturing quick and practical  

Disadvantages:

Proteins with disulfide bonds hard to communicate  Produce unglycosylated proteins  Proteins created with endotoxins  Acetic acid derivation development bringing about cell lethality   Proteins created as consideration bodies  produce dormant proteins  needs collapsing  

YEAST SYSTEM

Advantages:

Nearness of post translational change  discharge can be recognized by emission signal   develop in minimal effort media  straightforward hereditary control  

Disadvantages:

Low yeild of item  

Bacillus articulation frameworks  

Advantages:

Solid discharge   no association of intracellular consideration bodies  Simplicity of control  Hereditarily all around portrayed frameworks  Exceptionally created change and quality substitution advancements.  Unrivaled development qualities  financially savvy recuperation  

Animal Cells:

Advantage:

nearness of post interpretation adjustment  

Disadvatages

Issues with creature utilization  

Can get sullied with creature diseases  

Exorbitant downstream preparing

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