As an environment changes, and some organisms have a higer fitness than others, naturla selection acts directly
on

americans began to notice growing differences between the northern and southern sections of the country. there were more people living in cities in the north, which made it more urban. more people lived on farms in the south, which made it more rural. while many people were farmers in the northern states, there were now other ways to make a living, such as working in mechanical cotton gins factories manufacturing cloth, tools and other goods. people in the north supported high tariffs on goods imported from europe because the extra cost encouraged people to “buy american” instead. in the southern states, planters did not like tariffs because they sold most of their production to europe and bought their tools from there as well. southerners believed the protective tariff was something that only northern factory owners keep their profits high. so the southern politicians came up with an idea. they would opt out. they would simply ignore the protective tariff. it was ‘null and void’ in south carolina. the state would not collect the taxes on goods imported into south carolina, no matter what the president said they had to do. this decision led to the nullification crisis.

try using substitution:

x + y - 6 = x - y. (i'm not giving you the exact answer). since 0 = x - y, then sub 0 in the equation with x - y. combine your like terms, and then use inverse operations, and you'll have your answer.

: -)

it would lead to upper respiratory infections and pneumonia.

this is true, assuming that the allele is completely recessive and incomplete dominance is not a factor.