The map shows the Fertile Crescent. A map of the Fertile Crescent. The Caspian Sea in north and east of the Fertile Crescent. The Mediterranean Sea is west of the Fertile Crescent. The Red Sea is south of the Fertile Crescent. The Persian Gulf is south and east of the Fertile Crescent. A river extends from north of Mesopotamia, splits into The Euphrates River and Tigris River, toward the Persian Gulf. The Nile River is east of the Red Sea. The Jordan River is north of the Red Sea. Which major river flows into the Mediterranean Sea? the Nile River the Tigris River the Jordan River the Euphrates River