What was the most significant obstacle in building the transcontinental railroad?

There were many obstacles for building the First Transcontinental Railroad, including the Native Americans who sometimes actively impeded railroad construction, the many buffalo that inhabited the west, and of course the physical obstacles such as the rivers and canyons that had to be crossed and mountains that had to .

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the secretary of state, appointed by the president with the advice and consent of the senate, is the president's chief foreign affairs adviser. the secretary carries out the president's foreign policies through the state department and the foreign service of the united states.