What events led to a conflict between the jamestown settlers and the powhatan confederacy?

In 1622 colonists killed a Powhatan leader, the Powhatan responded by attacking the Virginia settlers later that year, fighting between the colonists and the Powhatan continued for the next 20 years.

Explanation:

when your a dog and you need a bone.   go and eat a rabbit

answer; make a no-nonsense accusation of the other;