Over the long term, the most significant threat to U. S. interests in the Indian Ocean region is .

India

Explanation:

India is the most significant threat to U.S. interests in the Indian Ocean because it is the only country of the region that has the potential of becoming a superpower.

This is because India is the second-most populated country in the world (after China) with a population of over 1,300 million people. Besides, because India has a higher population growth than China, it will become the most populated country in the near future.

The country is also developing fast after undergoing liberal economic reforms in the last decades.

The increased wealth and development will allow Indian governments to invest more in the military, and perhaps, become a real adversary for the U.S. in the long-term.

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