Atransient shortage of oxygen (global ischemia) releases excess glutamate into the extracellular fluid of the brain. this causes neuronal death by hyperexcitation to a greater extent in the hippocampus than in the cortex. which reason best explains why the hippocampus is selectively vulnerable during global ischemia?

Explanation:

The hippocampus becomes selectively unprotected because the receptor of the NMDA becomes more pronounced in the hippocampus than in the cortical neurons and this leads to a situation where by the hippocampus becomes more exposed to extracellular glutamate whose release is in excess.

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