The focus on neuroscience box, "the neuroscience of personality: brain structure and the big five," described an mri study that investigated whether personality traits are associated with differences in brain structure. researchers found that was associated with larger brain tissue volume in a brain region associated with sensitivity to rewarding stimuli, and was associated with increased volume in a brain region associated with understanding the beliefs of others.

Researchers found that "extraversion" was associated with larger brain tissue volume in a brain region associated with sensitivity to rewarding stimuli, and "agreeableness" was associated with increased volume in a brain region associated with understanding the beliefs of others.

Extraversion was related with bigger cerebrum tissue volume in the average orbitofrontal cortex, a brain region that is related with affectability to remunerating stimuli.

Agreeableness was related with expanded volume in the back cingulate cortex, a cerebrum locale related with understanding the convictions of others; likewise connected with more noteworthy volume in the fusiform gyrus, a zone of the cortex specific for seeing appearances.