Mrs. Grayson the much loved teacher of first grade retired last year at age seventy two.

No Change

Mrs. Grayson, the much loved teacher of first-grade, retired last year at
age seventy-two.

Mrs. Grayson, the much-loved teacher of first grade, retired last year at
age seventy-two.

Mrs. Grayson, the much loved teacher of first grade, retired last year at
age seventy two,

Mrs. Grayson, the much loved teacher of first grade, retired last year.

Explanation:

The subject of this sentence is Mrs. Grayson, and the sentence says she retired last year at age seventy two. "The much loved teacher" describes Mrs. Grayson, and should have a comma after (and before it).

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