Why does trisomy and monosomy occur? And why are they so bad on the molecular level?

Because the Monosomy (the lack of one member of a chromosome pair) and trisomy (a triplet instead of the normal chromosome pair) are typically the result of nondisjunction during meiosis. When this happens, one gamete shows monosomy, and the other shows trisomy of the same chromosome.In general, a monosomic for a particular chromosome is more severely abnormal than is the corresponding trisomic. trisomy 13, 18, 21, Triploidy and Turner syndrome: the 5T's.

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Explanation:

it will take around no amount of ruffe to knock over this 110lbs man because he semms to be around 300lbs. lol