pharmacokinetics is the study of a. what reaction a drug has on the body b. the various uses that one drug may serve within the body c. the reaction of drug when taken with other drugs d. what reaction the body has on a drug

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.

Keywords: Absorption, adverse drug reaction, distribution, drug-drug interactions, excretion, metabolism, poly-therapy

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thousands of years before the arrival of the british, australia was settled by the indigenous people of australia called the aborigines. this timeline begins when the europeans first arrived. 1606 - the first european to land at australia is dutch explorer captain willem janszoon.

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