When a hormone is present in normal or increased amounts but the expected actions of the hormone are not present, this is said to be a case of

This case is called hormonal resistance.

Explanation:

Hormonal resistance is a situation in which a hormone is present in normal or increased amounts but there´s no biological effect. This can occur as the result of a defective receptor or decrease in the affinity of this with its specific ligand (the hormone). Hormonal resistance is caused by genetic alterations or mutations.

For example, there is a pathology called resistance to thyroideus hormones which is majorly caused by mutations in the receptors of thyroideus hormones. This situation implies an alteration to the response of the action of thyroideus hormones what leads to an increase in this hormone, but the expected effect is not seen. Thyroideus hormones play an important role in the regulation of the metabolism, brain development, and others. So, the previous situation leads to a dysregulation principally in the metabolism in the body. if is a central resistance the person will have hypothyroidism but if it is peripheric the person will present hyperthyroidism

Another example of hormonal resistance could be the insulin resistance, which is seen in so many diabetics patients in those days. The insulin regulates the metabolism of glucose, so when this situation is observed, the patients although they have levels of this hormone in normal or higher concentration, the physiological effect is not observed.

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