Mathematics, 30.07.2019 17:10 ayeletstrauss
An investigator wants to conduct a funded study of the safety of a vaccine to prevent hepatitis c involving prisoners as subjects. prisoners will receive either a vaccine or a placebo and then be asked to complete surveys and undergo physical exams to assess for adverse effects. in order to ensure that subjects will report side effects and cooperate with exams, prisoners who are judged by the guards to be most compliant and wellâbehaved are nonrandomly assigned to the experimental arm; others are assigned to the control (placebo) arm. to encourage participation, prisoners are offered better meals and the opportunity for betterâpaying jobs in the prison.
select all aspects of this study that one could reasonably object to.
1. prisoners may consent to participation simply to obtain better meals and a better paying job (undue influence).
2. the study is funded, which would assume that the interests are purely financial instead of for the safety of the subjects, and thus the results cannot be trusted.
3. this study does not necessarily put the "interest of the subject ahead of the interests of science and society."
4. prisoners are too different from the general population, so we would not be able to make inferences about the general population based on the study's results.
5. the guards will sell the vaccines to sick prisoners to supplement their income illegally.
6. this is a nonârandomized clinical trial.
Answers: 1
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