Which of the following could be limitations to being able to use a precedent to decide a court case? (select all that apply.)

some of the facts of the original case are significantly different than the current case.
the original case was decided in a different type of court than the current case.
the judge in the original case did not have jurisdiction to try the case.
the ruling was made by a lower court than the court hearing the current case.
the judge in the ruling case did not use all the facts presented when making a decision.

Asubject in a clinical research trial experiences a serious, unanticipated adverse drug experience. how should the investigator proceed, with respect to the irb, after the discovery of the adverse event occurrence? a. do not report the adverse drug experience to the irb since it is a common adverse experience. b. report the adverse drug experience to the irb only if there are several other occurrences. c. report the adverse drug experience as part of the continuing review report. d. report the adverse drug experience in a timely manner, in keeping with the irb's policies and procedures, using the forms or the mechanism provided by the irb