How did the arrival of europeans most strongly affect the native peoples of the americas?

The arrival of Europeans to the Americas after their discovery by Christopher Columbus in 1492 implied a series of radical changes in the lives of the natives.

The natives, until that time, had remained isolated against European civilizations: their only contact was with other native groups, with whom they shared social, cultural and even physical characteristics. The arrival of the Europeans implied a break in this regard, as it was the first contact with a group that was absolutely different from the American Indian groups.

Once the colonization of the continent by the Europeans had been arranged, a period of suffering began for the Native Americans. This period was marked by the wars of conquest, in which the Europeans prevailed for having more advanced weapons; diseases, since the arrival of Europeans caused large outbreaks of smallpox within native populations; and finally slavery, since the defeated natives were taken as slaves within the encomienda system, forced to work the lands that were once theirs.

from the conditions of the working class in england by friedrich engels,the main idea is :

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