How did the Louisiana Purchase and Corps of Discovery increase lead to changes in the landscape of the United States and increase migration

- "made the south's economy grow rapidly and a small effect that a lot of people don't know is that it made the more demand of slaves and cotton products. and also new states formed due to plantations growing in size."

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disease was the number one killer of native peoples. they had had little exposure to the diseases of europe. this led to some villages being almost completely wiped out and some tribes destroyed.

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