The leaders of the city-states of italy were what

Which is likely the most serious problem associated with an epidemic? 1. there are sometimes no cures to the diseases that spread. 2. people often die from the diseases that spread. 3. there are usually no ways to prevent people from getting ill. 4. people often don’t know they have a disease.

James ll caused problems during his reign because his religion was: protestant lutheran catholic

Can someone me write a paragraph on this topic i feel confused