Which of the four freedoms would likely face opposition? why?

Freedom to speech, worship, from want and fear.
Roosevelt delivered his speech 11 months before the US declared war on Japan. State of Union and the threat to other Democrats from World War that was being wades across the continents in the eastern hemisphere. The 1st two are protected by the 1st Amendment. The later 2 went went beyond the traditional Constitutional values protected by the US bill of rights

An example of a political opponent would be albert einstein hitler hated him because he was jewish a pacifist