What overall lesson for the colonies to separate from britain does jefferson outline in the second paragraph

 The second paragraph is stating that all men are created equal with equal rights, and Britain was denying our rights; life, liberty, and the pursuit of happiness. So we created a government to ensure that we keep those rights and nobody can do anything about it. And if by any chance the government starts to deny our rights, we the people have the right to change the way our government, or whoever is in charge. Even without the government, we would still have our rights (life, liberty, pursuit of happiness). Hope this helps, I'm not sure if that made sense.