When early Spanish explorers reached what is now the southwestern United States, they encountered a number of flourishing agricultural centers. When the French arrived a century later, they found many of those villages deserted. Whhat factors played the biggest role in that change?

When the French arrived a century after the Spanish, they noticed abandoned villages because:

When the Spanish came, they came with European illnesses such as small pox for which the Natives had no immunity to and so they died in very large numbers and had to abandon their villages.

A number of villages and societies also crumbled as a result of the Spanish fighting with them, taking their lands, and forcing them to work for the Spanish and some deserted their villages as a result.

In conclusion, war and disease led to those villages being abandoned.

Find out more on the impact of disease on the Natives at link.

Native Americans were wiped out by European diseases such as Smallpox which was introduced by the Spanish explorers

Explanation:

In the case described above, the factors that played the biggest role in that change, that is, the French arriving a century later, and then found many of those villages deserted is as a result of "Native Americans were wiped out by European diseases such as Smallpox which was introduced by the Spanish explorers."

This is evident in the fact that the Spanish explorers did similar things to the inhabitants of places like Colombia, Peru, and Chile when they got to Southern America, thereby destroying the health and mortality of the native population.

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