In Modern America, what events could possibly lead to the secession of states from the union? Be specific and include multiple scenarios if you can.

Disagreements over federal laws, goverment and matters, are the most likely cause for secession in Modern America.

For example, if the federal government passes a law that taxes certain economic activities very high, and these activities are very important for a particular state, that particular state could start a secessio process, although such process would not be likely to succeed.

Another possibility is if a state inhabitants simply become nationalist and start separatist movements.

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powers  are  denied  to the  national governmentin three distinct ways: some  powers, such as the  power  to levy duties on exports or prohibit the freedom of religion, speech, press, or assembly, are expressly  denied  to the  national government  in the  constitution.