How did the Great Dying create a huge demographic shift in the Americas?

The Great Dying caused massive social, economic, and cultural upheaval in numerous Amerindian societies. This was probably the major factor in the disintegration of the Aztec and Inca empires. The calamity also had a major impact on the development of the new Spanish empire in the Americas.

Explanation:

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the indians crossed artificial boundaries, setting the stage for conflict