Which part of the world during the early modern era (1400-1750) experienced the most dramatic transformation? europe, asia, africa, or the americas?

The Americas suffered the most dramatic transformation due to the arrival of the Europeans, mainly Spain and Britain.

Explanation:

While all continents went through a process of transformation during the early modern era, it was the Americas who suffered the greatest changes.  The arrival of Europeans in the 16th and 17th centuries caused radical transformations in the way people lived.  The British wiped out most of the native population in North America, while the Spanish imposed a whole new way of life on the indigenous communities, changing their language, religion, traditions, food, and customs.

After the arrival of the Europeans, life for the original inhabitants of the Americas would never be the same.