Which american indian nation risisted removal in a way that hurt the u. s. efforts in the southeast?

In 1830 the United States was a prosperous and rapidly growing nation with an unquenchable desire for new lands to settle. In that year President Andrew Jackson signed into law the Indian Removal Act, which provided for the general resettlement of eastern Native Americans to lands west of the Mississippi River. 

The second , larger puritan colony of massachusetts bay was conceived as a "city upon a hill". but it also struggled with internal turmoil like the salem witch trials and external conflicts like king philip's (metacom's) war.