How did the fact that the safavids were shiite muslims affect relations with the ottomans?

The Safavid Empire´s religion was Shi'a Islam and all other religions, and forms of Islam were prohibited.  

For over a century the Ottoman Empire and Safavid Persia fought over the control of the South Caucasus and Mesopotamia and dogmatic disputes: the Ottomans were Sunnis and believed the Shia Muslims of the Qizilbash sect were heretics.

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