Which of the descriptions best describes stage two of the general adaptation syndrome? select one: a. people in this stage experience headaches, stomach aches, and difficulty sleeping. b. the mind and body become more alert and you enter the fight-or-flight response. c. the body becomes more resistant than normal to disease and injury. d. the body can no longer resist the stressor, and you experience a temporary shutdown.

An _ exposure is a repeated or prolonged exposure(over months or years) that may bring about slowly developing symptoms.

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for

Which method of administration would result in the highest concentration of the drug in the brain?