The image shows healthy red blood cells and sickle cells. A diagram with 2 parts. Part A is titled Normal red blood cells. Normal red blood cells (RBS) flow easily through a vein. A cross section of RBC is shaped like a bow. Part B It titled Abnormal, sickled, red blood cells (sickle cells). A few normal red blood cells are being stopped from traveling through a vein by sticky sickle cells. A cross section of a sickle cell is labeled Abnormal hemoglobin form strands that cause sickle shape.

Which statement best explains how the sickle cells cause healthy tissue in other parts of the body to become diseased?
The sickle cells are blocking other red blood cells from carrying oxygen throughout the body.
The sickle cells are preventing healthy cells from undergoing mitosis to create new tissues.
The sickle cells are damaging the DNA in other red blood cells throughout the body.
The sickle cells are causing the artery to expand and damage surrounding tissue.