Apatient arrives at your local pharmacy with a prescription for oxycodone with all of the required information on the face of the prescription order. "refill four times" is written at the bottom. what should you do next?

1) If you are not the pharmacist, contact the pharmacist or pharmacists on duty; who should:
         1)  check to see for any signs if the prescription has been altered; and/or:  whether the prescription is valid (e.g. look up the prescribing practitioner on the actual prescription; consider the dosage, specialty of prescription; run through the database); 

and:  2)  regardless of (#1 above),
         call the physician or other licensed prescribing practitioner who wrote the prescription to verify.

Furthermore:

       Note:  All  prescription products containing oxycodone, including Percocet, Endocet, OxyContin, are Federally Controlled DEA Schedule 2 Controlled Substances—and may not be "refilled" under any circumstances—even if cases of valid prescriptions—all "refills" on that prescription are null and void, even with the prescriber's permission; and a new prescription must be issued each time in lieu of a refill.

        Doctors do make mistakes; and the pharmacist needs to verify the prescription—and ask about the "4 refills".