Substance addiction (use disorder) a. develops only when one has high tolerance. b. is another term for physical dependence. c. does not develop when the drug of interest is not associated with withdrawal. d. can be diagnosed without tolerance and withdrawal symptoms.

a. develops only when one has high tolerance

Explanation:

Drug addiction also known as substance addiction -–use disorder is a disease that affects a person's brain and behaviorial state that is characterized by compulsive drug use or compulsive engagement in rewarding behavior, despite negative consequences.

Tolerance is the ability of the body (or other organism) to resist the action of a poison, to cope with a dangerous drug or to survive infection by an organism.

In this concept it describes how one's body produces a diminished response to a drug because of repeated use.

Dependence is also known as a physical dependence that describes a irresistible physical or psychological need, especially for a chemical substance.