Which drug would be most likely to block pain sensation during a minor medical procedure? Group of answer choices A drug that decreases the permeability of K+ channels at rest. A drug that raises the resting membrane potential of pain sensing neurons. A drug that activates ligand gated sodium channels. A drug that opens Cl- channels at rest. A drug that decreases the threshold of the voltage gated sodium channels on pain sensing neurons.

1. A drug that raises the resting membrane potential of pain sensing neurons

2. A drug that opens Cl- channels at rest.

Explanation:

The pain is felt when the sensation of pain is perceived by the brain that is the sensation lies in the neurotransmission of the pain impulse to the brain.  The drugs are prepared in a way that interferes with the transmission of the impulse.

The action potential in a neuron is generated when the neuron membrane is depolarised therefore the drug which could block the neuron from depolarization will be most effective.

Also, the drug which could open the chlorine ions will be most effective as the chloride ion influx will cause hyperpolarization which will be difficult to be depolarised.

Thus, the selected options are correct.