An anesthesiologist completes preoperative teaching for a patient the night before surgery. The patient asks the nurse to clarify the reason methohexital [Brevital] will be given as an adjunct to the anesthetic. Which statement by the patient indicates understanding?A. Brevital allows a larger amount of inhaled anesthetic to be used without increased side effects. B. Brevital is given to enhance the analgesic and muscle relaxation effects of the inhaled anesthetic. C. Brevital is used to produce rapid unconsciousness before administration of the inhaled anesthetic. D. Brevital is used to reduce cardiovascular and respiratory depression caused by the inhaled anesthetic.

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Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for: a. neither of the subjects b. subject 603 only c. subject 20 only d. both of the subjects

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