A 6-month-old, 4.1 pound baby who was born at 26 weeks gestation will be given palivizumab (Synagis) for prophylaxis of respiratory syncytial virus (RSV) infection. The infant will be given palivizumab 15 mg/kg IM, dosed on actual weight. Which of the following statements are correct? (Select ALL that apply.)

A The dose of palivizumab, rounded to the nearest milligram, is 27 mg, to be administered by IM injection.
B The dose of palivizumab, rounded to the nearest milligram, is 29 mg, to be administered by IM injection.
C A correct site for administration in this patient is the anterolateral thigh muscle.
D A correct site for administration in this patient is the fatty tissue under the triceps.
E Frequent handwashing and wiping of hard surfaces with soap and water or disinfectant may help stop infection and spread of RSV.

For a 6-month-old, 4.1 pound (1,8 Kg) baby who was born prematurely, the prevention of RSV infection with Palivizumab-Synagis is done by administering a dose of palivizumab, rounded to the nearest milligram, is 27 mg (option A), to be administered by IM injection in the anterolateral thigh muscle (option C)

Explanation:

Palivizumab (Synagis) is a monoclonal antibody used to increase the defenses of children who have been born prematurely against infections such as respiratory syncytial virus (RSV).  The usual dose is 15 mg/kg weight intramuscular (IM) once a month, when there is a risk of virus infection.

In this case, according to the weight of the child, 4.1 pounds, the weight should be estimated in kilograms for the calculation of the dose.

1 pound = 0.45 Kg .

4.1 pounds correspond to 1,845 Kg .

Dosage = 1,845 Kg X 15 mg = 27 ,675  mg.

The nearest option to the required dose of medicine is 27 mg.

The specifications of the laboratory that markets the drug suggest IM administration on the anterolateral thigh muscle, and not perform it by another way or in another location, such as the buttock muscle.

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