The antimicrobial drug imidazole inhibits sterol synthesis. this would most likely interfere with

Eukaryotic plasma membranes.

Explanation:

Imidazole acts by the alteration of the cell membrane permeability of microorganisms (e.g susceptible yeasts and fungi) by blocking the synthesis of the primary cell sterol of the fungi (Ergosterol (demethylation of lanosterol is inhibited)). This impairs the systems of the enzyme Cytochrome P450 and other enzymes which are required for the fatty acid synthesis. Because of the changes in oxidative and peroxidative activities of the enzyme induced by the drug, toxic concentrations of hydrogen peroxide develop inside the cell and the overall effect is cell membrane disruption and cell death of the fungi.