Which of the following contributes to the development of type 1 dm (diabetes mellitus)?
a. autoantibodies that contribute to the destruction of beta cells
b. insulin resistance and beta cell failure
c. increase in insulin-antagonist hormone levels
d. diet and sedentary lifestyle

Autoantibodies that contribute to the destruction of beta cells contributes to the development of type I diabetes mellitus (DM)

Explanation:

The autoantibodies produced in the cells of the islet of Langerhans in the pancreas are the main contributors of type I diabetes mellitus, which is an autoimmune-mediated disease.

DM type I is caused due to inhibition of insulin secretion by the beta cells of the pancreas. The autoantibodies are produced due to the presence of autoantigens like GAD65 which causes autoimmune pathogenesis of the pancreatic beta cells.

Along with these autoantibodies, the T-cell receptors act as mediators in the destruction of beta cells which finally results in DM.