An ideal drug will have a toxic dose and a effective dose. g

The ideal drug will have a high toxic dose and a low effective dose. 
Hope this helps;-;

The person who utilize the progression principle will keep adding the difficulty of the exercise that he's doing, while the person who does not, will only stay stagnant.  the person that utilize progression principle, will get a stronger endurance because now his body is conditioned to do harsher routines.{the answer was already on verified)