Dependence upon a drug is characterized by a state of mental and physical abnormality when the drug is withdrawn. dependence is marked by a craving for the drug.

Explanation:

Actually, physical dependence refers to a specific physical condition caused by a chronic drug use, an abrupt drug withdrawal will cause physical symptoms which will be really unpleasant.

On the other hand, psychological dependence refers to emotional and motivational symptoms as an effect from partial or complete drug withdrawal. Common effects are depression, anxiety anhedonia.

Therefore, the correct words that completes perfectly the statements are physical and psychological.

is it multiple choice?