Name _ Period _

Changes in DNA- Reading Guide

Directions: You will be reading pages 144-148 of your textbook while completing the following Reading Guide

BEFORE reading, read the statement below and predict whether or not the statement is TRUE or FALSE. AFTER reading, evaluate your response.

Before
Statement
After
t
Genes determine your height, skin color, and eye color.

f
Genetic mutations are always bad.

t
An individual can carry the gene for a disorder and not be affected by the disorder.

t
Most cancers are caused by mutations.

Pause, Stop, Reflect
What to ponder and think about
Written response
After you read the first 4 paragraphs

Humans all share 99.9% of the same DNA. Why is it that all humans have differences in their physical traits?

At “Check Your Reading”
What is a mutation?
A mutation occurs when a DNA gene is damaged or changed

At the bottom of page 145.
Take a minute to write about the three types of mutations and how they affect organisms.

At “Check Your Reading”
Explain what a genetic disorder is and how it affects the person with the disorder.

Sickle Cell Disease
Page 147

Answer the following questions about Sickle cell Disease in the Right Column.
What causes Sickle Cell Disease?

What happens to the red blood cells in a person that is recessive for Sickle Cell?

What are the negative affects of Sickle Cell?

What is a positive effect of having the allele for Sickle Cell?

At the bottom of
Page 147.
Think About It: In what part of the world is Sickle Cell Disease more common? Explain why you think it is more common in these parts of the world.

After Reading Page 148.
What effect does cancer have on the cell cycle of a cancerous cell?

**When you are finished with the Reading Guide, revisit the True and False questions at the beginning of this guide. **