The central flat region of north america is known as the

Interior Lowlands, the broad, generally flat areas of the central part of the North American continent. The name is used in regional geologic and physiographic descriptions of North America and the conterminous United States.  For Europeans, it was a new world, even though people already lived there.

PS. Did you know that the Vikings had already come to North America hundreds of years before, but they were short-lived colonies and nobody else knew about them?

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the rub-al-khali is also known as the arabian desert and the "empty quarter"