2 ways that Jews were targeted by the Catholic Church during Pope Paul IV's reign

He strengthen the influence of Inquisition and also created ghettos for Jews in the city of Rome, and even made them wear badges that was one way of presenting the difference between them and Christians. He even was encouraging Christians to treat Jews as they are citizens of less importance.

Explanation:

Pope Paul IV is regarded as one of the most infamous Popes in history because of his attitude toward other religions. He issued a (in)famous document, in which he ordered that the Jews should be distinguished from Christians. Jews even had to pay a building of their ghetto in the city of Rome.