A. Christopher Columbus enslaves native peoples in the Americas. B. Portugal conquers indigenous peoples in the Caribbean.
C. The Muisca religion becomes popular in South America.
O D. The Maya civilization spreads across Central America.
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Correct answer is C. The Muisca religion becomes popular in South America.

Explanation:

A is not correct answer as Columbus was the first to come to this region, which means that it couldn't happen before arrival of Europeans in Caribbean.

B is also not correct as Portugal came to this region after Columbus discovered America.

C is correct as Muisca religion is closely tied with Chibcha civilization. Actually Muisca people are even often called Chibcha. This religion mostly spread on the soil of todays Colombia.

D is not correct as Maya civilization reached its peak much earlier in their classical period which lasted until 9th Century.