Which of the following statements are true regarding zyvox? (select all that apply.)

a) it has excellent gram-positive coverage, including mrsa and vre.
b) it is cleared primarily by the kidney requiring dose adjustments in the setting of renal impairment.
c) monitor for serotonin syndrome when used with ssri antidepressants.
d) nephrotoxicity is a common toxicity with prolonged use.
e) it has excellent bioavailability, thus can transition from intravenous to oral formulations in a 1: 1 fashion

A,C,E

Zyvox = linezolid

Explanation:

Zyvox posses an excellent Gram positive coverage, as well as MRSA and VRE. Zyvox is primarily cleaned by the liver, the MAO inhibitor is expected to be administered with care along with Scrotonergic agents like SSRI, antidepressants, and it must be well monitored.

Bone marrow suppression is toxicity related with time and not Nephrotoxicity. Bioavailability in Zyvox is very excellent ; with transition from IV.PO with a ratio of 1:1.

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