If the heat of reaction is negative, that means that:

answer is: naturally occurring solid, inorganic compound or element is mineral.

minerals usually have crystalline form, that means than crystal constituents (atoms, molecules or ions) are arranged in a highly ordered microscopic structure, forming a crystal lattice that extends in all directions.

for example magnetite is a mineral of iron oxide (fe₂o₃).

calcite is a carbonate mineral and the most stable polymorph of calcium carbonate (caco₃).

dolomite is an   carbonate mineral composed of calcium magnesium carbonate (camg(co₃)₂).

answer is: nuclear fusion produces elements that are heavier than helium.

nuclei combine to form a heavier nucleus, releasing energy.  

for example, fusion of hydrogen atoms at the sun.  

this fusion nuclear reaction is in the inner core of the sun and hydrogen (atomic number 1) is conveted into helium (atomic number 2).  

the inner core is the central region of the sun and all solar energy is produced in the core by nuclear fusion.