1 Give the mechanism for the synthesis of tyrbostin from benzaldehyde. Show how the carbanion is generated from malononitrile (NCCH2CN) and stabilised (5 marks).

Show the reaction of the carbanion with the benzaldehyde (5 marks). Show how the

resulting alkoxide (O-) is protonated (5 marks). Show how the alkene bond is formed

(5 marks)

CN

ON

&

NCCH2CN

Piperidine

Aldehyde

Tyrphostin

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Focus

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most historians agree that gabriel mouton, the vicar of st. paul’s church in lyons, france, is the “founding father” of the metric system. he proposed a decimal system of measurement in 1670. mouton based it on the length of one minute of arc of a great circle of the earth (now called a nautical mile, 1852 meters). he also proposed the swing-length of a pendulum with a frequency of one beat per second as the unit of length (about 25 cm). a pendulum beating with this length would have been fairly easy to produce, thus facilitating the widespread distribution of uniform standards. over the years, his work was revised, improved, and extended by a number of french scientists.

the political sponsor of weights and measures reform in the french revolutionary national assembly was the bishop of autun, better known as talleyrand. under his auspices, the french academy appointed several committees to carry out the work of developing a usable system of weights and measures for france. one of the committees recommended a decimalized measurement system based upon a length equal to one ten-millionth of the length of a quadrant of the earth’s meridian (i.e., one ten-millionth of the distance between the equator and the north pole).