Determine the effect each given mutation would have on the rate of glycolysis in muscle cells. a. loss of binding site for fructose 1 ,6-bisphophate in pyruvate kinase.
b. loss of allosteric binding site for ATP in pyruvate kinase.
c. loss of allosteric binding site for AMP in phosphofructokinase.
d. loss of regulatory binding site for ATP in phosphofructokinase.

1. Increase
2. decrease
3. No effect