Determine the net change in NADHNADH , FADH2FADH2 , and GTPGTP from the passage of two acetyl-SCoA molecules through the citric acid cycle. Degradation of one molecule of glucose yields two acetyl-SCoA molecules. How many molecules of each of the cofactors are produced when these two acetyl-SCoA molecules pass through the citric acid cycle?

The citric acid cycle is the final common pathway for the aerobic oxidation of fuel molecules. Moreover, as we will see shortly (Section 17.3) and repeatedly elsewhere in our study of biochemistry, the cycle is an important source of building blocks for a host of important biomolecules. As befits its role as the metabolic hub of the cell, entry into the cycle and the rate of the cycle itself are controlled at several stages.

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