Changing pressure has the greatest affect on

Depends on the occasion

as with reaction where there is an equilibrium established pressure will effect the yield of the given reaction to either favour the left or right side

pressure affects the boiling point of molecules as it either makes molecules to be closer together or further and that affects their boiling point

pressure has an effect on the properties of substances as it can alter their physical properties 

hope that helps 

Hello.the answer is  hydrosphere, geosphere, and biosphere  have a nice day