An allosteric enzyme that is analogous to ATCase and follows the concerted mechanism (MWC model) has a T/R ratio of 300 in the absence of substrate. Suppose that a mutation reversed the ratio. How would this mutation affect the relationship between the rate of the reaction (V) and substrate concentration ([S])? Select all that apply. a. The enzyme would mostly be in the T form. b. The plot of V vs. [S]would be shaped like an S, sigmoidal. c. The enzyme would likely follow Michaelis-Menten kinetics. d. The enzyme would be more active. e. The plot of V vs. [S] would be shaped like a hyperbola.