As an approximation, we can assume that proteins exist either in their native (physiologically relevant) state or in a denatured state. The standard molar enthalpy and entropy of denaturationof a certain protein are 512 kJ/mol and 1.60 kJ/(mol K), respectively. Assume that DHand DSare independent of temperature. a. Commenton the signs thinking about protein denaturation. b. Calculate the standard molar free energy of denaturation. c. Calculate the temperature at which the denaturation becomes spontaneous.

Explanation:

a) The standard molar enthalpy of denaturation of protein = ΔH = 512 kJ/mol

The standard molar entropy of denaturation of protein = ΔS = 1.60 kJ/mol K

The Gibbs free energy is given by ;

ΔG = ΔH - TΔS

Here in the question value ΔH and ΔS are positive and independent of temperature.

This means that value of Gibbs free energy depends only upon temperature that is at lower denaturation of protein will be non spontaneous and at high temperatures denaturation of protein will spontaneous.

b) The standard molar free energy of denaturation of protein at 25°C.

T = 25°C = 25+273 K = 298 K

ΔG = ΔH - TΔS

  = 512 kJ/mol - 298 K × (1.60 kJ/mol K) =  35.2 kJ/mol

c) If the value ,ΔG < 0, then reaction is spontaneous.

Putting , ΔG =  0

ΔG = ΔH - TΔS

0 =512 kJ/mol - T × (1.60 kJ/mol)

512 kJ/mol =T × (1.60 kJ/mol K)

So, this means that above 320 Kelvins the denaturation of protein will be spontaneous.

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